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VOL. 8, ISSUE 2 (2023)
Decreased biliary secretion, biliary composition and serum electrolytes with chronic administration of Cannabis sativa in albino wistar rats
Authors
Okon V E, Obembe A O, Osim E E
Abstract
The effect of oral administration of Cannabis sativa on
biliary secretion and electrolytes was studied using albino Wistar rats.15
rats(200-250g) were randomly assigned into 3 groups; control, low dose and high
dose groups and administered 0.5ml/100g body weight of normal
saline,0.25ml/100g body weight of Cannabis sativa, and 0.4ml/100g body
weight of Cannabis sativa respectively. The results showed that the rate
of bile secretion was significantly (P<0.001) lower in the Cannabis
sativa groups compared to control with the high dose group being
significantly(P<0.05) lower compared to the low dose group. Biliary
electrolytes(Na+, K+ and Cl-)were
significantly(P<0.001) lower in the test groups dose dependently compared to
control. Biliary HCO3- however was significantly
increased(P<0.001) in the high dose group compared to control and low dose
groups. Biliary urea and creatinine levels were significantly(P<0.001) lower
in the test groups compared to control. Biliary cholesterol levels was
significantly(P<0.05) increased in the low dose group and
significantly(P<0.01) decreased in the high dose group compared to control. The
serum electrolytes (Na+, K+, and Cl-)were
significantly(P<0.001) lower in the test groups dose dependently compared to
control. At high dose, serum urea and creatinine levels were
significantly(P<0.001) increased compared to control and low dose group,
even though they were increased at low doses. The high dose group showed
significantly(P<0.001)increased glucose concerntration compared to control and
low dose while serum cholesterol levels was significantly(P<0.01) increased
in the test groups compared to control. Cannabis sativa may reduce bile
secretion dose dependently and may alter the concerntration of biliary
electrolytes. Therefore, the indiscriminate use of Cannabis sativa should
be discouraged.
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Pages:21-25
How to cite this article:
Okon V E, Obembe A O, Osim E E "Decreased biliary secretion, biliary composition and serum electrolytes with chronic administration of <i>Cannabis sativa </i>in albino wistar rats". National Journal of Multidisciplinary Research and Development, Vol 8, Issue 2, 2023, Pages 21-25
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