This study aims to focus on the relationship between stress and quality of life among diabetic patients. Diabetes is a long-term chronic disorder which forces an individual to make modifications in his/her lifestyle in order to balance the metabolism of the physical body. The imbalance of insulin levels in the body causes Stress in patient's life. Stress in the result acts as a barrier for effective glucose control in the body which has a direct effect on fight-or-flight tendency of the individual, which causes further imbalances in the cognitive abilities of an individual. These disturbances in thoughts due to stress deeply affect the life of an individual and deplete the quality of life. The formulated hypothesis was rejected and the findings indicated that stress and quality of life of the diabetic patients were found to be negatively correlated at the significance level of 0.01. Stress with diabetes can wear you down mentally and physically this makes managing the illness more difficult and affects the quality of life deeply.